New treatments to fight a rare disorder wreaking havoc in isolated indigenous...
Macquarie University researchers have developed the first zebrafish model of the neurodegenerative Machado-Joseph Disease – and have used this model to test drugs that could potentially be used to...
View ArticleHyperglycemia may cause caries but not periodontal disease
(HealthDay)—For rodents with diabetes, periodontal inflammation may be derived from dental caries rather than periodontal disease (PD), according to a study published online Aug. 9 in Diabetes.
View ArticleA tumor-suppressing gene can be harmful in some cancers
The TET2 tumor suppressor gene helps guard against blood cancers and perhaps protects against heart disease. Mutations in the gene affect about 1% of people over the age of 65, making them more...
View ArticleNewly deciphered vitamin D regulatory pathway opens doors to clinical research
Biochemists at the University of Wisconsin–Madison have deciphered the molecular mechanisms that underpin how the synthesis of the active form of vitamin D is regulated in the kidney, summing up...
View ArticleNew virtual model reveals details of declining lung function in mice
Scientists have developed a new virtual model of mouse lung function that illuminates the relative importance of different factors that contribute to lung changes accompanying chronic inflammation....
View ArticleLow-cost preventive care may help heart health for people with serious mental...
People with serious mental illness, such as bipolar disease and schizophrenia, die on average 25 years earlier than their peers. A common cause of death is heart disease that frequently develops...
View ArticleOn a quest to improve treatments for inflammatory bowel disease
Scientist Shomyseh Sanjabi, PhD, joined the Gladstone Institutes seven years ago, and she brought with her a special type of mice that develop inflammatory bowel disease (IBD). Coincidentally,...
View ArticleNew model may help science overcome the brain's fortress-like barrier
Scientists have helped provide a way to better understand how to enable drugs to enter the brain and how cancer cells make it past the blood brain barrier.
View ArticlePET imaging tracks Zika virus infection, disease progression in mouse model
For the first time, scientists have used Positron Emission Tomography (PET) imaging to study brain inflammation following Zika virus infection in mice, according to a study recently published online in...
View ArticleModelling our hearts
Recent television advertisements graphically illustrate what someone might look like when they are having a heart attack.
View ArticleNew tools to combat kidney fibrosis
Interstitial fibrosis – excessive tissue scarring – contributes to chronic kidney disease, which is increasing in prevalence in the United States.
View ArticlePossible approach discovered for treating multiple sclerosis
Around 2.5 million people are affected by the autoimmune disease multiple sclerosis (MS), the most common central nervous system disease among young adults. There are around 12,500 MS sufferers in...
View ArticleTransplanted hematopoietic stem cells reverse damage caused by neuro-muscular...
Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia...
View ArticleDrexel researchers identify 'master regulator' involved in infant lung damage
Researchers at Drexel University have revealed that inhibiting the micro-RNA miR-34a significantly reduces bronchopulmonary dysplasia (BPD) in mice. BPD is a chronic lung disease that affects up to...
View ArticleEpidemiology expert creates modeling framework to better predict outbreaks
A mathematical epidemiology expert at Georgia State University School of Public Health has published a new framework for building mathematical models to better predict the trajectory of infectious...
View ArticleModel predicts development of chronic kidney disease
(HealthDay)—A multivariable model that uses routine laboratory data is able to predict advanced chronic kidney disease after hospitalization with acute kidney injury, according to a study published...
View ArticlePatient-centered medical home model improves chronic disease management
Data from more than 800 Veterans Health Administration (VHA) primary care clinics revealed that national implementation of a patient-centered medical home model was effective at improving several...
View ArticlePreclinical study demonstrates promising treatment for rare bone disease
Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have led a preclinical study demonstrating that the drug palovarotene suppresses the formation of bony tumors (osteochondromas)...
View ArticleChildren with Alagille Syndrome have malformed bile ducts
Serious liver and heart problems can affect children with Alagille Syndrome early in life. While there is as yet no cure, researchers at Karolinska Institutet in Sweden have discovered that the liver...
View ArticleNew study points the way to therapy for rare cancer that targets the young
After years of rigorous research, a team of scientists has identified the genetic engine that drives a rare form of liver cancer. The findings offer prime targets for drugs to treat the usually lethal...
View ArticleStem cell-derived intestine model mimics innate immune responses
A stem cell-derived in vitro model displays key small intestine characteristics including innate immune responses, according to a study published November 29, 2017 in the open-access journal PLOS ONE...
View ArticleSocial media trends can predict tipping points in vaccine scares
Analyzing trends on Twitter and Google can help predict vaccine scares that can lead to disease outbreaks, according to a study from the University of Waterloo.
View ArticleScheduled feeding improves neurodegenerative symptoms in mice
Restricting meals to the same time each day improves motor activity and sleep quality in a mouse model of Huntington's disease, according to new research published in eNeuro. These findings suggest...
View ArticleNew AI technology significantly improves human kidney analysis
The ability to quantify the extent of kidney damage and predict the life remaining in the kidney, using an image obtained at the time when a patient visits the hospital for a kidney biopsy, now is...
View ArticleNew study validates clotting risk factors in chronic kidney disease
In late 2017, researchers from Boston University School of Medicine (BUSM) discovered and published (Science Translational Medicine, (9) 417, Nov 2017) a potential treatment target to prevent chronic...
View ArticleBrain signals for drug screening
There are still comparatively few treatments available for brain diseases. Among other reasons, this is due to the difficulty of developing new drugs, as it is not easy to establish the effects and...
View ArticleAntioxidant therapy prevents devastating vision loss when added to...
A new study led by vision researchers at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo and VA Western New York Healthcare System has demonstrated that the addition...
View ArticleHDAC6 inhibitors protect against neuronal damage and have therapeutic...
Inhibiting HDAC6 improves the structural stability of cells and protects against neuronal damage. Leuven research uncovered that targeting this mechanism could be a promising therapeutic approach for...
View ArticleScientists create most sophisticated human liver model yet
Scientists at Wake Forest Institute for Regenerative Medicine (WFIRM) have developed the most sophisticated mini-livers to date. These organoids can potentially help scientists better understand...
View ArticleKeeping an eye on the entire ageing process
Medical researchers often only focus on a single disease. As older people often suffer from multiple diseases at the same time, however, we need to rethink this approach, writes Ralph Müller.
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